| 9-113 | HJ Tayfield | South Africa v England | 1956/57 | t437 |
| 8-53 | GB Lawrence | South Africa v New Zealand | 1961/62 | t517 |
| 7-61 | MJ Hoggard | England v South Africa | 2004/05 | t1734 |
| 7-61 | SN Thakur | India v South Africa | 2021/22 | t2445 |
| 6-8 | DW Steyn | South Africa v Pakistan | 2012/13 | t2072 |
| 6-17 | SCJ Broad | England v South Africa | 2015/16 | t2199 |
| 6-21 | VD Philander | South Africa v Australia | 2017/18 | t2302 |
| 6-34 | AK Davidson | Australia v South Africa | 1957/58 | t444 |
| 6-53 | TL Goddard | South Africa v Australia | 1966/67 | t611 |
| 6-53 | A Kumble | India v South Africa | 1992/93 | t1201 |
| 6-53 | AA Donald | South Africa v England | 1999/00 | t1471 |
| 6-56 | AA Nortje | South Africa v Sri Lanka | 2020/21 | t2401 |
| 6-58 | PS Heine | South Africa v Australia | 1957/58 | t444 |
| 6-79 | PJ Cummins | Australia v South Africa | 2011/12 | t2018 |
| 6-81 | PS de Villiers | South Africa v Pakistan | 1994/95 | t1283 |
| 6-96 | PS Heine | South Africa v Australia | 1957/58 | t449 |
| 6-100 | M Ntini | South Africa v Australia | 2005/06 | t1795 |
| 5-20 | TE Bailey | England v South Africa | 1956/57 | t434 |
| 5-21 | GD McGrath | Australia v South Africa | 2001/02 | t1590 |
| 5-28 | Mohammed Shami | India v South Africa | 2017/18 | t2294 |
| 5-34 | DW Steyn | South Africa v New Zealand | 2007/08 | t1846 |
| 5-35 | M Ntini | South Africa v New Zealand | 2005/06 | t1801 |
| 5-37 | CS Martin | New Zealand v South Africa | 2005/06 | t1801 |
| 5-39 | PM Pollock | South Africa v Australia | 1969/70 | t672 |
| 5-40 | S Sreesanth | India v South Africa | 2006/07 | t1823 |
| 5-42 | CR Matthews | South Africa v New Zealand | 1994/95 | t1276 |
| 5-46 | GD McKenzie | Australia v South Africa | 1966/67 | t611 |
| 5-46 | MA Wood | England v South Africa | 2019/20 | t2382 |
| 5-51 | DW Steyn | South Africa v England | 2009/10 | t1948 |
| 5-51 | D Olivier | South Africa v Pakistan | 2018/19 | t2341 |
| 5-52 | GB Lawrence | South Africa v New Zealand | 1961/62 | t523 |
| 5-52 | DW Steyn | South Africa v Pakistan | 2012/13 | t2072 |
| 5-54 | SM Pollock | South Africa v West Indies | 1998/99 | t1429 |
| 5-54 | JJ Bumrah | India v South Africa | 2017/18 | t2294 |
| 5-59 | DW Steyn | South Africa v New Zealand | 2007/08 | t1846 |
| 5-64 | BE Hendricks | South Africa v England | 2019/20 | t2382 |
| 5-70 | D Gough | England v South Africa | 1999/00 | t1471 |
| 5-70 | VD Philander | South Africa v Australia | 2011/12 | t2018 |
| 5-74 | AA Donald | South Africa v England | 1999/00 | t1471 |
| 5-77 | MN Hart | New Zealand v South Africa | 1994/95 | t1276 |
| 5-78 | K Rabada | South Africa v England | 2015/16 | t2199 |
| 5-83 | FJ Cameron | New Zealand v South Africa | 1961/62 | t517 |
| 5-83 | PJ Cummins | Australia v South Africa | 2017/18 | t2302 |
| 5-84 | R Benaud | Australia v South Africa | 1957/58 | t449 |
| 5-84 | DG Cork | England v South Africa | 1995/96 | t1315 |
| 5-94 | M Ntini | South Africa v West Indies | 2003/04 | t1674 |
| 5-97 | DA Renneberg | Australia v South Africa | 1966/67 | t616 |
| 5-101 | MVT Fernando | Sri Lanka v South Africa | 2020/21 | t2401 |
| 5-104 | J Srinath | India v South Africa | 1996/97 | t1350 |
| 5-110 | AA Nortje | South Africa v England | 2019/20 | t2382 |
| 5-125 | I Meckiff | Australia v South Africa | 1957/58 | t444 |
| 5-125 | JW Gleeson | Australia v South Africa | 1969/70 | t672 |
| 5-129 | PM Pollock | South Africa v England | 1964/65 | t572 |
| 5-144 | MJ Hoggard | England v South Africa | 2004/05 | t1734 |
