| 7-29 | KJ Abbott | South Africa v Pakistan | 2012/13 | t2075 |
| 7-68 | MG Johnson | Australia v South Africa | 2013/14 | t2119 |
| 7-112 | K Rabada | South Africa v England | 2015/16 | t2200 |
| 6-32 | K Rabada | South Africa v England | 2015/16 | t2200 |
| 6-34 | DW Steyn | South Africa v West Indies | 2014/15 | t2150 |
| 6-37 | D Olivier | South Africa v Pakistan | 2018/19 | t2338 |
| 6-39 | M Zondeki | South Africa v Zimbabwe | 2004/05 | t1740 |
| 6-39 | LT Ngidi | South Africa v India | 2017/18 | t2293 |
| 6-49 | DW Steyn | South Africa v New Zealand | 2007/08 | t1848 |
| 6-50 | K Rabada | South Africa v West Indies | 2022/23 | t2495 |
| 6-52 | M Jansen | South Africa v Pakistan | 2024/25 | t2572 |
| 6-54 | Mohammad Abbas | Pakistan v South Africa | 2024/25 | t2572 |
| 6-71 | LT Ngidi | South Africa v India | 2021/22 | t2443 |
| 6-80 | CA Walsh | West Indies v South Africa | 1998/99 | t1441 |
| 6-81 | A Nel | South Africa v England | 2004/05 | t1736 |
| 6-86 | GD McGrath | Australia v South Africa | 1996/97 | t1362 |
| 6-99 | Shakib Al Hasan | Bangladesh v South Africa | 2008/09 | t1895 |
| 6-127 | Rahat Ali | Pakistan v South Africa | 2012/13 | t2075 |
| 5-20 | M Morkel | South Africa v India | 2010/11 | t1985 |
| 5-33 | DW Steyn | South Africa v New Zealand | 2016 | t2220 |
| 5-36 | AA Donald | South Africa v Australia | 1996/97 | t1362 |
| 5-36 | AA Nortje | South Africa v West Indies | 2022/23 | t2495 |
| 5-44 | Mohammed Shami | India v South Africa | 2021/22 | t2443 |
| 5-47 | DW Steyn | South Africa v New Zealand | 2005/06 | t1798 |
| 5-47 | KAJ Roach | West Indies v South Africa | 2022/23 | t2495 |
| 5-49 | AA Donald | South Africa v West Indies | 1998/99 | t1441 |
| 5-49 | M Ntini | South Africa v West Indies | 2003/04 | t1682 |
| 5-49 | VD Philander | South Africa v Sri Lanka | 2011/12 | t2023 |
| 5-51 | M Ntini | South Africa v New Zealand | 2005/06 | t1798 |
| 5-53 | VD Philander | South Africa v Sri Lanka | 2011/12 | t2023 |
| 5-54 | AA Donald | South Africa v Sri Lanka | 1997/98 | t1414 |
| 5-59 | MG Johnson | Australia v South Africa | 2013/14 | t2119 |
| 5-59 | D Olivier | South Africa v Pakistan | 2018/19 | t2338 |
| 5-59 | K Rabada | South Africa v India | 2023/24 | t2520 |
| 5-61 | D Paterson | South Africa v Pakistan | 2024/25 | t2572 |
| 5-63 | M Muralitharan | Sri Lanka v South Africa | 1997/98 | t1414 |
| 5-81 | AS Joseph | West Indies v South Africa | 2022/23 | t2495 |
| 5-83 | M Ntini | South Africa v Pakistan | 2006/07 | t1828 |
| 5-86 | N Wagner | New Zealand v South Africa | 2016 | t2220 |
| 5-89 | Mohammad Asif | Pakistan v South Africa | 2006/07 | t1828 |
| 5-94 | M Ntini | South Africa v New Zealand | 2005/06 | t1798 |
| 5-102 | JC Archer | England v South Africa | 2019/20 | t2377 |
| 5-110 | GP Swann | England v South Africa | 2009/10 | t1942 |
| 5-123 | PL Harris | South Africa v England | 2009/10 | t1942 |
| 5-136 | MR Gillespie | New Zealand v South Africa | 2007/08 | t1848 |
