| P | W | T | L | D | A | AT | BatBP | BowBP | Adj | Pts | AvPts | |||
| 1 | Hampshire Second XI | 9 | 7 | 0 | 1 | 1 | 0 | 0 | 16 | 27 | 0 | 163 | 18.111 | |
| 2 | Durham Second XI | 9 | 5 | 0 | 1 | 2 | 1 | 0 | 17 | 22 | 0 | 143 | 15.889 | |
| 3 | Leicestershire Second XI | 7 | 4 | 0 | 2 | 1 | 0 | 0 | 17 | 20 | 0 | 109 | 15.571 | |
| 4 | Middlesex Second XI | 9 | 5 | 0 | 2 | 1 | 1 | 0 | 13 | 23 | 0 | 132 | 14.667 | |
| 5 | Yorkshire Second XI | 11 | 3 | 0 | 1 | 6 | 1 | 0 | 29 | 26 | 0 | 159 | 14.455 | |
| 6 | Glamorgan Second XI | 10 | 4 | 0 | 2 | 2 | 2 | 0 | 20 | 19 | 0 | 135 | 13.5 | |
| 7 | Nottinghamshire Second XI | 11 | 4 | 0 | 4 | 3 | 0 | 0 | 28 | 29 | 0 | 145 | 13.182 | |
| 8 | Worcestershire Second XI | 8 | 3 | 0 | 2 | 2 | 1 | 0 | 18 | 15 | 0 | 105 | 13.125 | |
| 9 | Essex Second XI | 9 | 3 | 0 | 3 | 2 | 1 | 0 | 22 | 24 | -11 | 107 | 11.889 | |
| 10 | Lancashire Second XI | 12 | 3 | 0 | 3 | 5 | 1 | 0 | 22 | 23 | 0 | 141 | 11.75 | |
| 11 | Gloucestershire Second XI | 10 | 3 | 0 | 3 | 4 | 0 | 0 | 13 | 19 | 0 | 112 | 11.2 | |
| 12 | Northamptonshire Second XI | 9 | 3 | 0 | 4 | 2 | 0 | 0 | 14 | 17 | 0 | 95 | 10.556 | |
| 13 | Somerset Second XI | 9 | 3 | 0 | 5 | 1 | 0 | 0 | 10 | 25 | 0 | 91 | 10.111 | |
| 14 | Warwickshire Second XI | 10 | 3 | 0 | 4 | 1 | 1 | 1 | 8 | 20 | 0 | 100 | 10 | |
| 15 | Surrey Second XI | 7 | 1 | 0 | 3 | 3 | 0 | 0 | 13 | 17 | 0 | 70 | 10 | |
| 16 | Derbyshire Second XI | 10 | 1 | 0 | 5 | 2 | 1 | 1 | 12 | 19 | 0 | 79 | 7.9 | |
| 17 | Sussex Second XI | 9 | 0 | 0 | 6 | 3 | 0 | 0 | 21 | 17 | 0 | 62 | 6.889 | |
| 18 | Kent Second XI | 7 | 0 | 0 | 6 | 1 | 0 | 0 | 9 | 18 | 0 | 35 | 5 |
| Points Awarded and Column Key: | |
| Won (W): 16 | |
| Tied (T): 8 | |
| Lost (L): 0 | |
| Drawn (D): 8 | |
| Abandoned without a ball bowled (A): 8 | |
| Abandoned without a ball bowled (but toss made) (AT): 8 | |
| Batting Bonus Points (BatBP) | |
| Bowling Bonus Points (BowBP) | |
| Adjustments (carried forward/fines/penalty points) (Adj) | |
| Total points (Pts) | |
| Average points per match (AvPts) |
| Order in the table: | |
| Position of teams in the table is determined by: | |
| Average points per match | |
| Won |
| Adjustments: | |
| Essex Second XI: 11 points deducted for slow over-rate in match against Durham Second XI on 12th April 2021 |
| Notes: | |
| Essex Second XI and Sussex Second XI combined to play two matches - both teams took full points from these matches and are classified as a match for each team. As teams played differing number of matches, average points per match was adopted to determine league positions. | |
| Essex Second XI and Sussex Second XI combined to play two matches - both teams took full points from these matches and are classified as a match for each team. As teams played differing number of matches, average points per match was adopted to determine league positions. | |
| Essex Second XI and Sussex Second XI combined to play two matches - both teams took full points from these matches and are classified as a match for each team. As teams played differing number of matches, average points per match was adopted to determine league positions. |