| 301 runs | KwaZulu-Natal Women v Limpopo Women | Polokwane Cricket Club Ground, Polokwane | wa8509 |
| 242 runs | Northern Cape Women v Kei Women | De Beers Diamond Oval, Kimberley | wa8638 |
| 213 runs | KwaZulu-Natal Women v Mpumalanga Women | Sahara Stadium Kingsmead, Durban | wa8617 |
| 203 runs | Boland Women v Kei Women | Khaya Majola Oval, Mthatha | wa8501 |
| 190 runs | Easterns Women v Limpopo Women | Polokwane Cricket Club Ground, Polokwane | wa8497 |
| 190 runs | Northerns Women v Border Women | Hammanskraal Oval, Hammanskraal | wa8625 |
| 183 runs | Western Province Women v Border Women | United Cricket Club Ground, East London | wa8518 |
| 174 runs | South Western Districts Women v Northern Cape Women | Recreation Ground, Oudtshoorn | wa8660 |
| 161 runs | KwaZulu-Natal Inland Women v Limpopo Women | City Oval, Pietermaritzburg | wa8659 |
| 150 runs | Easterns Women v KwaZulu-Natal Inland Women | Sahara Park Willowmoore, Benoni | wa8623 |
| 138 runs | South Western Districts Women v Kei Women | Khaya Majola Oval, Mthatha | wa8519 |
| 132 runs | Eastern Province Women v Kei Women | St George's Park No 2 Ground, Port Elizabeth | wa8622 |
| 116 runs | Boland Women v Eastern Province Women | St George's Park No 2 Ground, Port Elizabeth | wa8635 |
| 111 runs | Free State Women v Border Women | Police Ground, East London | wa8658 |